Effect of Purslane Extract (Portulaca oleracea L.) on Hypoxic Rat Organs

Febriofca Galih Yatalaththov, Nabilah Adzra Fahlevi, Benta Lenggar, Rita Maliza

Abstract


Hypoxia occurs when the body experiences a lack of oxygen or an increase in cellular oxygen consumption. A lack of oxygen can affect the production of reactive oxygen species (ROS). High levels of ROS can cause various diseases and damage to the body. Antioxidant compounds can suppress this increase in ROS. The purslane plant (Portulaca oleracea L.) has the potential to be a source of antioxidants. This study aimed to examine the compounds and observe the effect of purslane plant extract on repairing and reducing organ damage in the lungs, hearts, and brains of hypoxic rats. Observation parameters for organ morphology were reviewed using organ index measurements and histopathology. The results indicate that two substances, 3,7,11,15-Tetramethyl-2-hexadecen-1-ol and 12-Methyl-E,E-2,13-octadecadien-1-ol, have the potential to be antioxidants, and the weight ratio of lung organs in each treatment did not differ significantly (P > 0.05). At doses of 150 and 300 mg/kgBW, the parameter of inflammatory cells in the hypoxia group was significantly different from the control group (P < 0.05). Based on the histology of the lung, heart, and brain organs of rats, it can be determined that hypoxic tissue in the control group does not undergo a repair process, resulting in necrosis, hemorrhage, and an increase in inflammatory cells.


Keywords


Portulaca oleracea L.; Antioxidant; Hypoxia; Inflammatory cells; Necrosis

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DOI: http://dx.doi.org/10.52155/ijpsat.v44.1.6135

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