Synthesis Gold Nanoparticles as Advanced Computed Tomography Contrast Agents using Pulsed Laser Ablation Method

Nadia Maulika Purnama Wafi, Eko Hidayanto, Ali Khumaeni

Abstract


In this study, gold nanoparticles (Au NPs) were successfully synthesized using the pulsed laser ablation technique with an Nd:YAG laser. The successful formation of these nanoparticles was evidenced by the color change of the colloid from translucent to purple. The synthesized Au NPs were then evaluated and compared to iodine-based contrast agents at three different kVp settings: 80 kVp, 100 kVp, and 120 kVp. When applied as CT contrast agents, Au NPs exhibited superior performance, as demonstrated by the maximum CT Number value of 7.43 HU and the maximum Contrast-to-Noise Ratio of 2.85, which significantly surpassed the performance of the widely used iodine-based contrast agent across the tested kVp variations. The results in this experiment hints that Au NPs hold significant potential as effective contrast agents for CT-Scan imaging techniques.

Keywords


Pulsed laser ablation; gold nanoparticles; Computed Tomography; Contrast agent.

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References


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DOI: http://dx.doi.org/10.52155/ijpsat.v49.1.6995

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