The Potential of Secondary Metabolites from Cinnamomum sp. as Natural Insecticide Against Mosquitoes
Abstract
Mosquitoes are the primary vectors of various infectious diseases such as dengue fever, malaria, and filariasis, making their control a crucial public health concern. One environmentally friendly alternative for mosquito control is the use of plant-based natural insecticides, such as Cinnamomum sp., which is known to contain bioactive compounds like cinnamaldehyde, eugenol, and linalool. These compounds exhibit insecticidal activity through neurotoxic mechanisms, repellency, antifeedant effects, and inhibition of mosquito larval growth. This study is a literature review that collects and analyzes various studies on the effectiveness of Cinnamomum sp. extract against mosquitoes. The review findings indicate that Cinnamomum sp. extract has high potential as a natural insecticide, demonstrating toxic effects on both mosquito larvae and adults while also act as an effective repellent. Additionally, the use of this extract is safer for the environment compared to synthetic insecticides. Therefore, Cinnamomum sp. could serve as a viable alternative for biological vector control, although further research is needed to optimize its formulation and field application.
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Nakasen, K., Wongsrila, A., Prathumtet, J., Sriraj, P., Boonmars, T., Promsrisuk, T., ... & Aukkanimart, R. (2021). Bio efficacy of Cinnamaldehyde from Cinnamomum verum essential oil against Culex quinquefasciatus (Diptera: Culicidae). Journal of Entomological and Acarological Research, 53(1).
Halstead, S. B. (2019). Dengue hemorrhagic fever. In CRC Handbook of Viral and Rickettsial Hemorrhagic Fevers (pp. 85-94). CRC Press.
Tananchai, C., Manguin, S., Bangs, M. J., & Chareonviriyaphap, T. (2019). Malaria vectors and species complexes in Thailand: implications for vector control. Trends in parasitology, 35(7), 544-558.
Gianchecchi, E., Cianchi, V., Torelli, A., & Montomoli, E. (2022). Yellow fever: origin, epidemiology, preventive strategies and future prospects. Vaccines, 10(3), 372.
Hayes, C. G. (2019). West nile fever. In The arboviruses (pp. 59-88). CRC Press.
Wright, D., Kortekaas, J., Bowden, T. A., & Warimwe, G. M. (2019). Rift Valley fever: biology and epidemiology. Journal of General Virology, 100(8), 1187-1199.
Masmejan, S., Musso, D., Vouga, M., Pomar, L., Dashraath, P., Stojanov, M., ... & Baud, D. (2020). Zika virus. Pathogens, 9(11), 898.
Wijayanti, S. P., Sunaryo, S., Suprihatin, S., McFarlane, M., Rainey, S. M., Dietrich, I., ... & Kohl, A. (2016). Dengue in Java, Indonesia: relevance of mosquito indices as risk predictors. PLoS neglected tropical diseases, 10(3), e0004500.
Mahmoud, H. A., Azab, M. M., & Sleem, F. M. (2023). Bioactivity of Cinnamomum verum powder and extract against Cryptolestes ferrugineus S., Rhyzopertha dominica F. and Sitophilus granarius L.(Coleoptera). International Journal of Tropical Insect Science, 43(2), 629-636.
Xu, Y., Qin, J., Wang, P., Li, Q., Yu, S., Zhang, Y., & Wang, Y. (2020). Chemical composition and larvicidal activities of essential oil of Cinnamomum camphora (L.) leaf against Anopheles stephensi. Revista da Sociedade Brasileira de Medicina Tropical, 53, e20190211.
Kang, M. S., & Lee, H. S. (2018). Acaricidal and insecticidal responses of Cinnamomum cassia oils and main constituents. Applied Biological Chemistry, 61, 653-659.
Mdoe, F. P., Cheng, S. S., Msangi, S., Nkwengulila, G., Chang, S. T., & Kweka, E. J. (2014). Activity of Cinnamomum osmophloeum leaf essential oil against Anopheles gambiae ss. Parasites & vectors, 7, 1-6.
Jeon, Y. J., Lee, S. G., Yang, Y. C., & Lee, H. S. (2017). Insecticidal activities of their components derived from the essential oils of Cinnamomum sp. barks and against Ricania sp.(Homoptera: Ricaniidae), a newly recorded pest. Pest management science, 73(10), 2000-2004.
Liu, X. C., Cheng, J., Zhao, N. N., & Liu, Z. L. (2014). Insecticidal activity of essential oil of Cinnamomum cassia and its main constituent, trans-cinnamaldehyde, against the booklice, Liposcelis bostrychophila. Tropical Journal of Pharmaceutical Research, 13(10), 1697-1702.
Firmino, D. F., Cavalcante, T. T., Gomes, G. A., Firmino, N. C., Rosa, L. D., de Carvalho, M. G., & Catunda Jr, F. E. (2018). Antibacterial and antibiofilm activities of Cinnamomum sp. essential oil and cinnamaldehyde: antimicrobial activities. The Scientific World Journal, 2018(1), 7405736.
Savitri, E. S., Holil, K., Resmisari, R. S., Syarifah, U., & Munawaroh, S. (2019). Effect of extraction solvent on total phenol, total flavonoid content and antioxidant activities of extract plants Punica granatum, Vitis vinifera L, Ficus carica L. and Olea europea. In AIP Conference Proceedings (Vol. 2120, No. 1). AIP Publishing.
Nurcahyo, H., Sumiwi, S. A., Halimah, E., & Wilar, G. (2020). Total flavonoid levels of ethanol extract and ethyl acetate fraction dry shallots (Allium cepa l. Var. garden onion of brebes) with maceration methods using uv-vis spectrophotometry. Systematic Reviews in Pharmacy, 11(10), 286-289.
Surya, A., Mahardika, D. P., Zaiyar, Z., & Sepriani, H. (2021). Antidiabetic activity of Jering skin extract (Pithecellobium jiringa) with dichloromethane (DCM) solvent fraction. In AIP Conference Proceedings (Vol. 2360, No. 1). AIP Publishing.
Abdelbaky, A. S. (2021). Effect of various extraction methods and solvent types on yield, phenolic and flavonoid content and antioxidant activity of Spathodea nilotica leaves. Egyptian Journal of Chemistry, 64(12), 7583-7589.
Hussain, Z. T., Yagi, S., Mahomoodally, M. F., Mohammed, I., & Zengin, G. (2019). A comparative study of different solvents and extraction techniques on the anti-oxidant and enzyme inhibitory activities of Adansonia digitata L.(Baobab) fruit pulp. South African Journal of Botany, 126, 207-213.
Ibi, A. A., & Kyuka, C. K. (2022). Sources, extraction and biological activities of cinnamaldehyde. Trends in Pharmaceutical Sciences, 8(4), 263-282.
Rastegar, S., Kargarsharifabad, H., Rahbar, N., & Shafii, M. B. (2020). Distilled water production with combination of solar still and thermosyphon heat pipe heat exchanger coupled with indirect water bath heater–experimental study and thermoeconomic analysis. Applied Thermal Engineering, 176, 115437.
Chaiphongpachara, T., Laojun, S., & Wassanasompong, W. (2020). Screening seven commercial essential herb oils for larvicidal activity against the mosquito Aedes aegypti (Linnaeus), a vector of the dengue virus. Journal of Applied Pharmaceutical Science, 10(7), 043-050.
Yu, T., Yao, H., Qi, S., & Wang, J. (2020). GC-MS analysis of volatiles in cinnamon essential oil extracted by different methods. Grasas Y aceites, 71(3), e372-e372.
Shetty, V., Chellampillai, B., & Kaul-Ghanekar, R. (2020). Development and validation of a bioanalytical HPLC method for simultaneous estimation of cinnamaldehyde and cinnamic acid in rat plasma: application for pharmacokinetic studies. New Journal of Chemistry, 44(11), 4346-4352
Marek, G., Dobrzański Jr, B., Oniszczuk, T., Combrzyński, M., Ćwikła, D., & Rusinek, R. (2020). Detection and differentiation of volatile compound profiles in roasted coffee arabica beans from different countries using an electronic nose and GC-MS. Sensors, 20(7), 2124.
Chansang, A., Champakaew, D., Junkum, A., Amornlerdpison, D., Chaithong, U., Jitpakdi, A., ... & Pitasawat, B. (2018). Potential of natural essential oils and cinnamaldehyde as insecticides against the dengue vector Aedes aegypti (Diptera: Culicidae). Southeast Asian J. Trop. Med. Public Health, 49(1), 6-22.
Zhang, J., Huang, T., Zhang, J., Shi, Z., & He, Z. (2018). Chemical composition of leaf essential oils of four Cinnamomum species and their larvicidal activity against Anophelus sinensis (Diptera: Culicidae). Journal of Essential Oil Bearing Plants, 21(5), 1284-1294.
Dai, D. N., Chung, N. T., Huong, L. T., Hung, N. H., Chau, D. T., Yen, N. T., & Setzer, W. N. (2020). Chemical compositions, mosquito larvicidal and antimicrobial activities of essential oils from five species of Cinnamomum growing wild in north central Vietnam. Molecules, 25(6), 1303.
Narayanankutty, A., Kunnath, K., Alfarhan, A., Rajagopal, R., & Ramesh, V. (2021). Chemical composition of Cinnamomum verum leaf and flower essential oils and analysis of their antibacterial, insecticidal, and larvicidal properties. Molecules, 26(20), 6303.
Andrade-Ochoa, S., Sánchez-Aldana, D., Chacón-Vargas, K. F., Rivera-Chavira, B. E., Sánchez-Torres, L. E., Camacho, A. D., ... & Nevárez-Moorillón, G. V. (2018). Oviposition deterrent and larvicidal and pupaecidal activity of seven essential oils and their major components against Culex quinquefasciatus Say (Diptera: Culicidae): Synergism–antagonism effects. Insects, 9(1), 25.
Iqbal, J., Ishtiaq, F., Alqarni, A. S., & Owayss, A. A. (2018). Evaluation of larvicidal efficacy of indigenous plant extracts againstCulex quinquefasciatus (Say) under laboratory conditions. Turkish Journal of Agriculture and Forestry, 42(3), 207-215.
Parul, Singh, S. P., & Mohan, L. (2021). Bioefficacy of Cinnamomum tamala essential oil against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus larvae.
Sharawi, S. E. (2023). Larvicidal effect of some traditional Saudi Arabian herbs against Aedes aegypti larvae, a vector of dengue fever. bioRxiv, 2023-09.
Xu, Z., Chen, J., Shang, R., Yang, F., Xie, C., Liu, Y., ... & Wu, L. (2023). The Mosquito Larvicidal Activity of Lignans from Branches of Cinnamomum camphora chvar. Borneol. Molecules, 28(9), 3769.
Akono, P. N., Mbida, J. A. M., Dongmo, P. M. J., Tonga, C., Tchamga, L. A. D., Mounbain, F., ... & Kekeunou, S. (2016). Chemical composition and insecticidal activity of essential oils of Cinnamomum zeylanicum, Citrus grandis, Citrus medica and Citrus sinensis leaves from Cameroon on Anopheles gambiae Giles, 1902. J. Entomol. Zool. Stud, 4(6), 17-23.
Thomas, A., Mazigo, H. D., Manjurano, A., Morona, D., & Kweka, E. J. (2017). Evaluation of active ingredients and larvicidal activity of clove and cinnamon essential oils against Anopheles gambiae (sensu lato). Parasites & vectors, 10, 1-7
Moungthipmalai, T., Puwanard, C., Aungtikun, J., Sittichok, S., & Soonwera, M. (2023). Ovicidal toxicity of plant essential oils and their major constituents against two mosquito vectors and their non-target aquatic predators. Scientific Reports, 13(1), 2119.
Sanei-Dehkordi, A., Heiran, R., Roozitalab, G., Elahi, N., & Osanloo, M. (2022). Larvicidal effects of nanoliposomes containing clove and cinnamon essential oils, eugenol, and cinnamaldehyde against the main malaria vector, Anopheles stephensi Liston. Psyche: A Journal of Entomology, 2022(1), 9991238.
Aungtikun, J., & Soonwera, M. (2021). Improved adulticidal activity against Aedes aegypti (L.) and Aedes albopictus (Skuse) from synergy between Cinnamomum spp. essential oils. Scientific Reports, 11(1), 4685.
Vu, D. P. U., & Ho, D. M. (2022). Chemical Composition of Cinnamomum Cassia Oil in Vietnam and Its Spatial Repellent Effects Against the Aedes Aegypti. Journal of Technical Education Science, 17(Special Issue 01), 130-134.
Khater, H., E Soliman, D., Slim, A., Debboun, M., & M Baz, M. (2023). Larvicidal efficacy of fifteen plant essential oils against Culex pipiens L. mosquitoes in Egypt. Egyptian Journal of Veterinary Sciences, 54(2), 183-192.
Bangonan, L., Blore, K., Peper, S. T., Aryaprema, V. S., Bond, J., Qualls, W. A., & Xue, R. D. (2022). Laboratory Evaluation of Bigshot Maxim Against Three Species of Larval and Adult Mosquitoes, Aedes aegypti, Culex quinquefasciatus, and Anopheles quadrimaculatus. Journal of the American Mosquito Control Association, 38(1), 70-73. doi: https://doi.org/10.2987/21-7032
Firooziyan, S., Amani, A., Osanloo, M., Moosa-Kazemi, S. H., Basseri, H. R., Hajipirloo, H. M., ... & Sedaghat, M. M. (2021). Preparation of nanoemulsion of Cinnamomum zeylanicum oil and evaluation of its larvicidal activity against a main malaria vector Anopheles stephensi. Journal of Environmental Health Science and Engineering, 19, 1025-1034.
Pham, T. V., Ha, N. X., Luyen, N. D., Xuan, T. H., Le Quoc, T., Hung, N. H., & The, S. N. (2023). Chemical composition, mosquito larvicidal and antimicrobial activities, and molecular docking study of essential oils of Cinnamomum melastomaceum, Neolitsea buisanensis and Uvaria microcarpa from Vietnam. Chemistry & Biodiversity, 20(9), e202300652.
Mahran, H. A., Aboelhadid, S. M., & Hassan, K. M. (2023). Synthesis and efficacy of cinnamon oil formulations and their sustainable release against common house mosquito larvae. Beni-Suef University Journal of Basic and Applied Sciences, 12(1), 118.
Çimen, H. (2023). Mosquito oviposition deterring and larvicidal effect of cinnamaldehyde and eugenol. Journal of Anatolian Environmental and Animal Sciences, 8(3), 322-325.
Seenivasan, P., Tennyson, S., Jayakumar, M., & Prabu, A. (2019). Larvicidal activity of cinnamaldehyde against the filarial vector Culex quinquefasciatus. RJLBPCS, 5(3), 601-608.
Abutaha, N., Al-Mekhlafi, F. A., Al-Khalifa, M. S., & Wadaan, M. A. (2022). Larvicidal activity and Histopathological changes of Cinnamomum burmannii, Syzygium aromaticum extracts and their combination on Culex pipiens. Saudi Journal of Biological Sciences, 29(4), 2591-2596.
Sohipah, E., Purba, A. V., & Djamil, R. (2020). Development of gel for Aedes aegypti repellent with combination of cinnamon oil (Cinnamomum burmannii Blume) and fennel oil (Foeniculum vulgare Mill). Scripta Medica, 51(3), 198-202.
Farag, S. M., Moustafa, M. A., Fónagy, A., Kamel, O. M., & Abdel-Haleem, D. R. (2024). Chemical composition of four essential oils and their adulticidal, repellence, and field oviposition deterrence activities against Culex pipiens L.(Diptera: Culicidae). Parasitology Research, 123(1), 110.
Wahab, I. A., Jaliuddin, A. F., & Anuar, N. A. (2020). Mosquito repellency effects of the essential oils from Cinnamomum iners leaves and barks. In IOP Conference Series: Earth and Environmental Science (Vol. 596, No. 1, p. 012079). IOP Publishing.
Mustapa, M. A., Guswenrivo, I., Zurohtun, A., Khairul Ikram, N. K., & Muchtaridi, M. (2023). Analysis of essential oils components from aromatic plants using headspace repellent method against Aedes aegypti mosquitoes. Molecules, 28(11), 4269.
Sanga, A. G., Mazigo, H. D., Manjurano, A., Morona, D., Thomas, A., & Kweka, E. J. (2023). Measuring repellence and mortality effects of clove and cinnamon essential oils impregnated nets against Anopheles gambiae senso stricto using tunnel test. Journal of Natural Pesticide Research, 5, 100046.
Osanloo, M., Firoozian, S., Zarenezhad, E., Montaseri, Z., & Satvati, S. (2022). A nanoliposomal gel containing Cinnamomum zeylanicum essential oil with effective repellent against the Main Malaria Vector Anopheles stephensi. Interdisciplinary Perspectives on Infectious Diseases, 2022(1), 1645485.
Iriani, F. A., & Dehi, R. I. (2024). Repellent Activity Testing of an Essential Oil Gel Preparation of Cinnamon (Cinnamomun Burmanii) Bark) And Kaffir Lime Peel (Citrus Hytrix) Against Aedes Aegypti Mosquitoes. Oshada, 1(3), 89-101.
Surendran, S., KP, S., Pandian, A., Sivalingam, A. M., & Ramasubbu, R. (2024). Analysis of chemical composition and biological efficiency of leaf essential oils isolated from seven species of Cinnamomum of the Western Ghats, India. Biomass Conversion and Biorefinery, 1-32.
Ramkumar, G., Karthi, S., Shivakumar, M. S., & Kweka, E. J. (2019). Culex quinquefasciatus egg membrane alteration and ovicidal activity of Cipadessa baccifera (Roth) plant extracts compared to synthetic insect growth regulators. Research and Reports in Tropical Medicine, 145-151.
Sutiningsih, D., Nurjazuli, N., Nugroho, D., & Satoto, T. B. T. (2019). Larvicidal activity of brusatol isolated from brucea javanica (L) merr on Culex quinquefasciatus. Iranian Journal of Public Health, 48(4), 688.
Pavela, R., & Sedlák, P. (2018). Post-application temperature as a factor influencing the insecticidal activity of essential oil from Thymus vulgaris. Industrial crops and products, 113, 46-49.
Li, Y., Zou, J., Ren, X., Li, W., Wu, W., Xuan, Q., ... & Sheng, Z. (2024). Discovery of α-hexyl cinnamaldehyde and its derivatives as novel larvicides against Aedes albopictus. Arabian Journal of Chemistry, 105873
Benelli, G., Pavela, R., Petrelli, R., Cappellacci, L., Canale, A., Senthil-Nathan, S., & Maggi, F. (2018). Not just popular spices! Essential oils from Cuminum cyminum and Pimpinella anisum are toxic to insect pests and vectors without affecting non-target invertebrates. Industrial crops and products, 124, 236-243.
Nwanade, C. F., Wang, M., Li, H., Masoudi, A., Yu, Z., & Liu, J. (2022). Individual and synergistic toxicity of cinnamon essential oil constituents against Haemaphysalis longicornis (Acari: Ixodidae) and their potential effects on non-target organisms. Industrial Crops and Products, 178, 114614
DOI: http://dx.doi.org/10.52155/ijpsat.v50.1.6983
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