Optimization Of Antibiotic Production On Various Protein Substrates Against Staphylococcus aureus And Escherichia coli

Hanif Aulia Defnur, Nurmiati Nurmiati, Periadnadi Periadnadi

Abstract


Optimization has been carried out on the protein substrate, isolates of Slaughterhouse Waste. This study aims to determine the best protein substrate for potential antimicrobial isolates (Bacillus, Isolate Slaughterhouse Waste) in the production of antibiotics against the test bacteria S. aureus and E. coli. This study used an experimental method to optimize each of the different protein substrates in the production of antibiotics from potential isolates from the Slaughterhouse Waste tract against S. aureus and E. coli. From the results of the study, skim milk was obtained as the best substrate because it had the highest Halozone diameter of 15 mm against the test bacteria S. aureus and 9 mm against E. coli. Inhibition against S. aureus was strong, while for E. coli it was moderate.

 


Keywords


Antibiotics, Genus Bacillus, Skimmed Milk, Substrate Optimization

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DOI: http://dx.doi.org/10.52155/ijpsat.v28.2.3472

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