Anticancer activities of organogermanium compounds

Odularu Temidayo Ayodele

Abstract


Abstract

Among the diversed applications of germanium in biological, chemical, industrial, medical and pharmaceutical fields, this overview focuses on anticancer actions of organogermanium. Organogermanium compounds (OGCs) with their low toxic profiles are applied in different biological, medical and pharmaceutical fields than the inorganic germanium compounds. For anticancer studies, OGCs in previous studies were synthesized using both liquid and gaseous phases, but recently the use of wet chemical reduction method to synthesize capped water-dispersible (GeNPs) to help promote green chemistry is the encouraged practice.

Keywords: Organogermanium compounds, anticancer activities, wet chemical reduction method, nanoparticles of germanium, green chemistry.


Keywords


Keywords: Organogermanium compounds, anticancer activities, wet chemical reduction method, nanoparticles of germanium, green chemistry.

Full Text:

PDF

References


Editors of Encyclopedia Britannica” Germanium, 2016. [Online] Available” http://global.britannica.com/science/germanium” (accessed March 21, 2016).

C. L. Zhang, T. H. Li, S. H. Niu, R. F. Wang, Z. L.; Fu, F. Q. Guo and M. Yang, “Synthesis and Evaluation of Novel Organogermanium Sesquioxides as Antitumor Agents,” Bioinorganic Chemistry and Applications, vol. 2009, pp. 1-8, 2009.

X. Song, Z. Yang, Q. Xie and J. Li, “ Synthesis, Structures and In vitro Anticancer Activity of Some Germanium-Substituted Di-N-Butyltin Dipropionates,” Chemical Journal of Chinese Universities, vol 19, no. 8, pp. 361, 1998.

H. Bhattacharjee, B. P. Rosen, R. Mukhopadhyay, “Aquaglyceroporins and Metalloid Transport: Implications in Human Diseases,” Handbook on Experimental Pharmacology. vol. 190, pp. 309-325, 2009.

E. N. Tzanetou, K. M. Kasiotis, N. S. Thomaidis and E. Rosenberg,” Determination of Trace Inorganic Germanium in Bis-Beta-Carboxyethylgermanium Sesquinoxide by Headspace Solid-Phase Microextraction and Gas Chromatography-Mass Spectrometry, “ Current Analytical Chemistry, vol. 9, no. 2, pp. 244-249, 2016.

J. Vinodhini and S. Sudha, Effect of Bis-Carboxy Ethyl Germanium Sesquoxide on N-Nitroso-N-Methylurea-Induced Rat Mammary Carcinoma. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 2, pp. 242-244, 2013.

B. J. Kaplan, W. W. Parish, G. M. Andrus J. S. Simpson and C. J. Field, Germany Facts about Germanium Sesquioxide: 1. Chemistry and Anticancer Properties. Journal of Alternative and Complementary Medicine, vol.10, no. 2, pp. 337-344, 2004.

V. Jeyaraman and S. Sellappa, “In-vitro Anticancer Activity of Organic Germanium on Human Breast Cancer Cell Line (MCF-7),” Journal of Current Pharmaceutical Research, vol. 5, pp. 39-41, 2011.

J. Pi, J. Zeng, J. J. Luo, P. H. Yang and J. Y. Cai, Synthesis and Biological Evaluation of Germanium (IV)-Polyphenol Complexes as Potential Anti-cancer Agents. Bioinorganic Medicinal Chemistry Letter, vol. 23, pp. 2902-2908, 2013.

P. Köpf- Maier, C. Janiak, H. Shumann, “Antitumor Properties of Organometallic Metallocene Complexes of Tin and Germanium,” Journal of Cancer Research and Clinical Oncology, vol 114, pp. 502-506, 1988.

S. Sellappa, “Antibacterial Properties of Organic Germanium against Some Human Pathogens,” International Journal for Pharmaceutical Biological Science, vol. 2, pp. 854-859, 2011.

A.G. Schauss, “Nephrotoxicity and Neurotoxicity in Humans from Organogermanium Compounds and Germanium Dioxide. Biological Trace Element Research, vol. 29, no. 3, pp.267-280, 1991.

Takeuchi, N. Yoshizawa, S. Oshiwa, T. Kubola, Y. Oshikawa, Y. Akashi, T. Oda, H. Niwa, N. Imazeki and A. Seno,” Nephrotoxicity of Germanium Compounds: Report of a Case and Review of the Literature,” Nephron, vol. 60, no. 4, pp. 436-442, 1992.

V. G. Lakhtin, N. G. Komalenkova, V. G. Bykovchenko, G N. Yakovleva and E. A. Chernyshev,” Synthesis and Application of Organogermanium Compounds” Polymer Science, Series D. Glues and Sealing Materials, vol. 4, no. 3, pp. 221-227, 2011.

H. Yin, H. Cai, J. Teng and P. Yang “Facile Solutions Routes for the Syntheses of Water-Dispersable Germanium Nanoparticles and Their Biological Applications,” Materials Letters, vol. 109, no. 15, pp.108-111, 2013.

Odularu, Ayodele. "Review on Anticancer, Antimicrobial and Antitumour Activities of Antimony Complexes,"International Journal of Progressive Sciences and Technologies, vol. 1, no 2, pp. 25-27, 2015.

ODULARU, Ayodele Temidayo, "Bismuth and Its Wide Applications, " International Journal of Progressive Sciences and Technologies, vol. 2, no. 1, pp. 10-12, 2016.

ODULARU, Ayodele Temidayo, "Arsenic Compounds as Therapeutic Agents," International Journal of Progressive Sciences and Technologies, vol. 2, no. 1, pp. 21-23, 2016.

ODULARU, Ayodele Temidayo, "Boron Complexes as Anticancer Agents and Recent Advances," International Journal of Progressive Sciences and Technologies, vol. 2, no. 2, pp. 40-42, 2016.

ODULARU, Ayodele Temidayo,"Cobalt Compounds as Multifaceted Chemotherapeutic Agent: An Overview,"International Journal of Progressive Sciences and Technologies, vol. 2, no. 2, pp. 71-73, 2016.




DOI: http://dx.doi.org/10.52155/ijpsat.v3.1.24

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 Odularu Temidayo Ayodele

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.