The Effect of Cadmium Nanoparticles on Hepatic Enzymes Variation in Blood of Rattus

Shams Masoumeh, Ghaed Amini Nahid, Taei Somayeh, Haji Aghababa Alireza

Abstract


Nanoparticles can be used in disease detection, Medical imaging, Pharmaceutical Drug, cancer treatment, gene therapy, Cosmetics and textile productions. These materials accumulate in cells that create Oxidative stress because of reviving oxygen production. Cadmium is a toxic pollutant that has no constructive role in the body and is partially harmful. This metal can create oxidative stress in the body with an increase of free radicals and a decrease of antioxidant capacity that can be lead to the destructive effects in liver and kidneys. At first, nanoparticles of cadmium oxide was synthesized by chemical method in the library. The evaluation of these nanoparticles by X-Ray diffraction (XRD) confirmed that synthesized nanoparticles were cadmium oxide and an absorption was indicated in the 380nm area by Uv – vis spectrum of cadmium oxide's nanoparticles. Then, three concentrations of synthesized nanoparticles of cadmium oxide including 100, 200 and 300 ppm were used. Wister male rats were fed during 10 days through the mouth. After these periods, blood samples were taken from rats and creatine phosphate kinase, Alanine aminotransferase and AAspartate transaminase enzymes were measured. The results indicated that the enzymes concentration was increase in blood with increasing concentrations of treated nanoparticles and this increase was considerable and higher in groups that received the highest concentration. Also, it was significance in group with intermediate level of nanoparticles. 

Keywords


Cadmium Oxide nanoparticles, Alanine Aminotransferase, AAspartate Amino Transferase enzymes, enzyme Creatine Phosphate Kinase.

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DOI: http://dx.doi.org/10.52155/ijpsat.v5.2.156

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