Novel Insights into Exosomes and Cardiovascular Disorders

Maged Naser, Mohamed M. Nasr, Lamia H. Shehata

Abstract


Extracellular vesicles (EVs) are tiny biological entities, ranging from micro to nano size, surrounded by lipid layers that influence processes like cell movement, new blood vessel formation, and cancer cell proliferation by conveying various biomolecules such as DNA and proteins. EVs consist of exosomes, microparticles, and apoptotic bodies. Their advantages include their ability to pass through biofilms without being broken down by different enzymes, which makes them valuable potential biomarkers for diseases, garnering significant interest from the scientific community. Recent investigations indicate that EVs play a role in the progression of several cardiovascular diseases (CVD), including heart failure and injuries related to myocardial ischemia-reperfusion. Furthermore, EVs derived from stem cells are significant in diagnosing and treating different CVDs. This review discusses the biological characteristics of EVs, their involvement in various CVDs, and the hurdles they face in CVD treatment.


Keywords


Exosomes, cardiovascular disorders ,diagnosis , treatment .

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References


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DOI: http://dx.doi.org/10.52155/ijpsat.v55.1.7731

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