Smart Wound Dressings Integrating Biosensors for Real-Time Monitoring of Wound Conditions
Abstract
Biosensors have paved the way for significant advancements in the management of chronic wounds. Following Clarke's introduction of the oxygen electrode, biosensors have transformed into sophisticated bandages that autonomously release medications to address
Wounds based on physiological indicators, such as pH or glucose levels, that signify pathogenic threats. Aptamer based biosensors have been instrumental in detecting and characterizing harmful bacteria in wounds, which frequently develop antibiotic-resistant biofilms.
Numerous functional polymers have played vital roles in the development of these biosensors. Starting with natural polymers like alginate, chitosan, and silk derived fibroin, known for their biodegradable and absorptive properties, progress has occurred in creating biocompatible synthetic polymers like polyurethane and polyethyleneglycol, aimed at minimizing nonspecific binding of proteins and cells, thus making biosensors less painful or cumbersome for patients. Recently, polycaprolactone has been engineered, offering flexibility and an extensive surface-area-to volume ratio. There remains potential for further innovations in the production and application of biosensors for wound healing and this review emphasize the evolution from biomarker detection to smart dressings and the integration of machine learning in crafting personalized wound patches for prolonged use.
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DOI: http://dx.doi.org/10.52155/ijpsat.v48.2.6938
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