"Threads Of Innovation” - How Nanofibers Are Shaping Dermatology
Abstract
Background
Nanofibers are considered an innovative breakthrough in dermatology due to their extensive range of therapeutic applications and exceptional drug delivery selectivity. They are excellent delivery methods for biological agents such as corticosteroids, antibiotics, and anti-inflammatory drugs because of their high surface area, porosity, and biocompatibility. The effectiveness of treatment increases alongside the significant decrease in systemic adverse effects with this focused strategy. Furthermore, published research has shown nanofibers themselves include antibacterial qualities, which enable them to effectively treat ailments such as skin cancer, fungal infections, dermatitis, wounds, and pigmentation. The controlled release of active substances from nanofibers makes them vital in cosmetic dermatology, particularly in anti-aging treatments.
Materials and Methods
A literature review was performed by analyzing articles published on PubMed and Google Scholar, focusing on the keywords electrospun nanofibers, controlled drug release, noninvasive dermatological applications, wound healing, skin regeneration, and anti-aging. The role of nanofibers in delivering medications into the skin, addressing skin concerns, cosmetic applications, manufacturing and scaling of these fibers was among the primary areas of consideration
Results
Previously established results show evidence of nanofiber treatment preserving the stability of active formulations for acne treatment and their timely, dose-dependent distribution into the skin, avoiding side effects. They enhance the penetration of substances into deeper layers of skin, making them an effective scar treatment. For atopic dermatitis, nanofiber therapy reduces the frequency of medication application and controls moisture loss, providing hydration to the skin. Nanofibrils have revolutionized early skin cancer detection by capturing tumor biomarkers earlier than conventional methods. Nanofibers infused with Myrtus communis extracts and coenzyme Q10 show evidence of protection against UV-induced aging and boost skin regeneration. Electrospun nanofiber face masks also provide a non-invasive alternative to microneedling or laser treatments.
Conclusion
The unique quality nanofibers possess, such as their small size, high surface area, and enhanced penetration, enable their application in wound healing, tissue engineering, and enhancing treatments for acne, dermatitis, and skin cancer. However, challenges like high production costs, scalability, and biocompatibility concerns persist. Rigorous studies and cost-effective manufacturing techniques are essential for realizing their full potential in dermatology.
Keywords
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DOI: http://dx.doi.org/10.52155/ijpsat.v48.2.6886
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