Medical Therapy of Non-Compressible Haemorrhage

Abstract

Drug delivery systems are being developed for many treatments including hemostasis. Increasing the concentration of therapeutic coagulants in areas where tissue grows and can be achieved by applying them directly to the injury, such as through catheters or external devices, or by using therapeutic methods that target the expression of molecular markers of vascular damage. Excessive bleeding is difficult to treat with external measures because blood pressure pushes hemostatic drugs out, reducing their effectiveness. This review means that small particles can be used to deliver therapeutic agents such as coagulants, small molecules, or other chemical or biological agents that enter the wounds during bleeding. A recent example of a cross-sectional study showed that stimulation increased thrombin activity and tranexamic acid in the treatment of hemorrage in 2 murine bleeding models and a porcine model of fatal non-compressible bleeding. Numerous devices are available that expose bandages and new methods that make it easier to apply them to the site of vascular injury could reduce the number of deaths from bleeding worldwide.