Covid-19 And Jaundice In Infants

P. Machavariani, N. Khotivari, N. Metskhvarishvili, M. Rizvadze, E. Shevalshvili


In Tbilisi State Medical University First University Clinic Department of Perinatology, within a framework of retrospective study, the medical histories of 23 pregnant women in 2022 (infected with Sars-CoV-2 at different stages of pregnancy and childbirth) and their newborns were studied   which are  transferred in the Neonatal Intensive Care Unit (NICU), due to jaundice, for the  phototherapy  and further monitoring of bilirubin level. As it was determined by data analysis, in 17 out of 23 cases, SARS-CoV-2 infection during pregnancy and childbirth were characterized by a moderate or severe duration of infection, and their newborns were diagnosed with jaundice with an unspecified cause.

Based on our study, it can be assumed that   jaundice   in newborns, which appeared due to  hyperbilirubinemia  is a neonatal consequence of SARS-CoV-2 ,which  probably cause placental vascular malperfusion and polycythemia in fetuses, which may be a compensatory response to this infection.


COVID-19, SARS-CoV-2, NICU, Jundice

Full Text:



. Huang C ,Wang Y ,Li X ,et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.Lancet. 2020; (published online Jan 24.

. Ronald J Wong, BA, Vinod K Bhutani, MD, FAAP ,Unconjugated hyperbilirubinemia in neonates: Risk factors, clinical manifestations, and neurologic complications

. 3.Bhutani VK, Johnson L, Sivieri EM. , Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999;103:6–14.doi: 10.1542/peds.103.1.6.

. Association Between COVID-19 Pregnant Women Symptoms Severity and Placental Morphologic Features. Rebutini PZ, Zanchettin AC, Stonoga ETS, Prá DMM, de Oliveira ALP, Dezidério FDS, Fonseca AS, Dagostini JCH, Hlatchuk EC, Furuie IN, Longo JDS, Cavalli BM, Dino CLT, Dias VMCH, Percicote AP, Nogueira MB, Raboni SM, de Carvalho NS, Machado-Souza C, de Noronha L.Front Immunol. 2021 May 26;12:685919. doi: 10.3389/fimmu.2021.685919. eCollection 2021.PMID: 34122449



  • There are currently no refbacks.

Copyright (c) 2024 Maia Rizhvadze

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.