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Biomarkers and Diagnosis of Acute Appendicitis in Children: Review
Abstract
A ruptured appendix is quite possibly of the most regular careful crisis in pediatric medical procedure. Complicated appendicitis can develop with attached peritonitis portrayed by the dispersion of the pathological interaction to the peritoneal cavity, subsequently creating general or restricted inflammation of the peritoneum. The ability to expect the chance of perforation in acute appendicitis can coordinate brief management and lower morbidity. There are no particular symptoms that could be utilized to expect complicated infected appendix, and diagnostic hints incorporate a longer time of symptoms, diffuse peritoneal signs, high fever, raised leukocytosis , CRP, hyponatremia, and high ESR. Imagistic strategies, especially US and CT, are helpful yet not adequate. There are no traditional inflammation biomarkers ready to foresee the advancement of simple to complicated appendicitis alone, yet the prescient limit of novel biomarkers is being researched. The point of this review is to lay out the predictors that might help physicians in convenient recognizing pediatric patients determined to have intense appendicitis in risk of creating a ruptured appendix with development to attached peritonitis.
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- Rentea, Rebecca M., and Shawn D. St Peter. "Pediatric appendicitis." Surgical Clinics 97.1 (2017): 93-112.
- Andersson, Manne N., and Roland E. Andersson. "Causes of short-term mortality after appendectomy: a population-based case-controlled study." Annals of surgery 254.1 (2011): 103-107.
- Vissers, Robert J., and William B. Lennarz. "Pitfalls in appendicitis." Emergency Medicine Clinics 28.1 (2010): 103-118.
- Thompson, Graham C., et al. "Variation in the diagnosis and management of appendicitis at Canadian pediatric hospitals." Academic Emergency Medicine 22.7 (2015): 811-822.
- Beltrán, Marcelo A., et al. "Predictive value of white blood cell count and C-reactive protein in children with appendicitis." Journal of pediatric surgery 42.7 (2007): 1208-1214.
- Grönroos, J. M. "Do normal leucocyte count and C‐reactive protein value exclude acute appendicitis in children?" Acta Paediatrica 90.6 (2001): 649-651.
- Samuel, Madan. "Pediatric appendicitis score." Journal of pediatric surgery 37.6 (2002): 877-881.
- Alvarado, Alfredo. "A practical score for the early diagnosis of acute appendicitis." Annals of emergency medicine 15.5 (1986): 557-564.
- Andersson, Manne, and Roland E. Andersson. "The appendicitis inflammatory response score: a tool for the diagnosis of acute appendicitis that outperforms the Alvarado score." World journal of surgery 32.8 (2008): 1843-1849.
- Kharbanda, Anupam B., et al. "Development and validation of a novel pediatric appendicitis risk calculator (pARC)." Pediatrics 141.4 (2018).
- Goldman, Ran D., et al. "Prospective validation of the pediatric appendicitis score." The Journal of pediatrics 153.2 (2008): 278-282.
- Schneider, Carisa, Anupam Kharbanda, and Richard Bachur. "Evaluating appendicitis scoring systems using a prospective pediatric cohort." Annals of emergency medicine 49.6 (2007): 778-784.
- Godwin, Benjamin David, et al. "Is there a need to standardize reporting terminology in appendicitis?" Ultrasound quarterly 31.2 (2015): 92-94.
- Nielsen, Jason W., et al. "Reducing computed tomography scans for appendicitis by introduction of a standardized and validated ultrasonography report template." Journal of pediatric surgery 50.1 (2015): 144-148.
- Kearl, Y. Liza, et al. "Accuracy of magnetic resonance imaging and ultrasound for appendicitis in diagnostic and nondiagnostic studies." Academic Emergency Medicine 23.2 (2016): 179-185.
- Shommu, Nusrat S., et al. "The use of metabolomics and inflammatory mediator profiling provides a novel approach to identifying pediatric appendicitis in the emergency department." Scientific reports 8.1 (2018): 4083.
- Chawla, Lakhmir S., et al. "Acute appendicitis: transcript profiling of blood identifies promising biomarkers and potential underlying processes." BMC Medical Genomics 9 (2016): 1-11.
- Strimbu, Kyle, and Jorge A. Tavel. "What are biomarkers?" Current Opinion in HIV and AIDS 5.6 (2010): 463-466.
- Ozguner, İsmet F., et al. "Are neutrophil CD64 expression and interleukin-6 early useful markers for diagnosis of acute appendicitis?" European Journal of Pediatric Surgery (2013): 179-183.
- Sengupta, Anshuman, George Bax, and Simon Paterson-Brown. "White cell count and C-reactive protein measurement in patients with possible appendicitis." The Annals of The Royal College of Surgeons of England 91.2 (2009): 113-115.
- Kharbanda, Anupam B., et al. "Novel serum and urine markers for pediatric appendicitis." Academic Emergency Medicine 19.1 (2012): 56-62.
- Huckins, David S., et al. "A novel biomarker panel to rule out acute appendicitis in pediatric patients with abdominal pain." The American journal of emergency medicine 31.9 (2013): 1368-1375.
- Mickiewicz, Beata, et al. "Development of metabolic and inflammatory mediator biomarker phenotyping for early diagnosis and triage of pediatric sepsis." Critical care 19 (2015): 1-13.
- Naqvi, S. Ali, et al. "Cytokines and chemokines in pediatric appendicitis: a multiplex analysis of inflammatory protein mediators." Mediators of inflammation 2019 (2019).
- Shommu, Nusrat S., et al. "Metabolomic and inflammatory mediator-based biomarker profiling as a potential novel method to aid pediatric appendicitis identification." PLoS One 13.3 (2018): e0193563.
- Abdulkhaleq, L. A., et al. "The crucial roles of inflammatory mediators in inflammation: A review." Veterinary world 11.5 (2018): 627.
- Sproston, Nicola R., and Jason J. Ashworth. "Role of C-reactive protein at sites of inflammation and infection." Frontiers in immunology 9 (2018): 342848.
- Gogos, Charalambos A., et al. "Pro-versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options." The Journal of infectious diseases 181.1 (2000): 176-180.
- Albu, Eugene, et al. "Diagnostic value of C-reactive protein in acute appendicitis." Diseases of the colon & rectum 37 (1994): 49-51.
- Kharbanda, Anupam B., et al. "Discriminative accuracy of novel and traditional biomarkers in children with suspected appendicitis adjusted for duration of abdominal pain." Academic Emergency Medicine 18.6 (2011): 567-574.
- Groselj-Grenc, Mojca, et al. "Clinical and laboratory methods in diagnosis of acute appendicitis in children." Croatian medical journal 48.3 (2007): 353.
- Sack, Ulrich, et al. "Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children." BMC surgery 6 (2006): 1-8.
- Trapani, Sandra, Alessandra Montemaggi, and Giuseppe Indolfi. "Choosing wisely in pediatric healthcare: a narrative review." Frontiers in Pediatrics 10 (2023): 1071088.
- Cui, Wei, et al. "Diagnostic accuracy of procalcitonin for overall and complicated acute appendicitis in children: a meta-analysis." Italian Journal of Pediatrics 45 (2019): 1-7.
- Gavela, Teresa, et al. "C-reactive protein and procalcitonin are predictors of the severity of acute appendicitis in children." Pediatric emergency care 28.5 (2012): 416-419.
- de Kruif, Martijn D., et al. "Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department." Critical care medicine 38.2 (2010): 457-463.
- Fortunato, Antonio. "A new sensitive automated assay for procalcitonin detection: LIAISON® BRAHMS PCT® II GEN." Practical Laboratory Medicine 6 (2016): 1-7.
- Adams, H. Lꎬ, and S. S. Jaunoo. "Hyperbilirubinaemia in appendicitis: the diagnostic value for prediction of appendicitis and appendiceal perforation." European journal of trauma and emergency surgery 42 (2016): 249-252.
- Bonadio, William, et al. "Lack of utility of measuring serum bilirubin concentration in distinguishing perforation status of pediatric appendicitis." The American journal of emergency medicine 35.6 (2017): 885-888.
- Türkyilmaz, Z., et al. "Sequential cytokine levels in the diagnosis of appendicitis." Scandinavian Journal of Clinical and Laboratory Investigation 66.8 (2006): 723-732.
- Rivera-Chavez, Fernando A., et al. "Regional and systemic cytokine responses to acute inflammation of the vermiform appendix." Annals of surgery 237.3 (2003): 408-416.
- Fontes, Jillian A., Noel R. Rose, and Daniela Čiháková. "The varying faces of IL-6: From cardiac protection to cardiac failure." Cytokine 74.1 (2015): 62-68.
- Paajanen, H., et al. "Novel serum inflammatory markers in acute appendicitis." Scandinavian journal of clinical and laboratory investigation 62.8 (2002): 579-584.
- Kakar, Mohit, et al. "Determining acute complicated and uncomplicated appendicitis using serum and urine biomarkers: interleukin-6 and neutrophil gelatinase-associated lipocalin." Pediatric Surgery International 36 (2020): 629-636.
- Lycopoulou L, Mamoulakis C, Hantzi E et al. Serum amyloid A protein levels as a possible aid in the diagnosis of acute appendicitis in children. Clin. Chem. Lab. Med. 43(1), 49–53 (2005). Crossref. PubMed.
- Abbas, Muhammad H., et al. "Admission levels of serum amyloid a and procalcitonin are more predictive of the diagnosis of acute appendicitis compared with C-reactive protein." Surgical Laparoscopy Endoscopy & Percutaneous Techniques 24.6 (2014): 488-494.
- Andersson, Manne, et al. "Can new inflammatory markers improve the diagnosis of acute appendicitis?." World journal of surgery 38 (2014): 2777-2783.
- Allister, Lauren, et al. "Serum markers in acute appendicitis." Journal of Surgical Research 168.1 (2011): 70-75.
- Kentsis, Alex, et al. "Detection and diagnostic value of urine leucine-rich α-2-glycoprotein in children with suspected acute appendicitis." Annals of emergency medicine 60.1 (2012): 78-83.
- Kentsis, Alex, et al. "Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry." Annals of emergency medicine 55.1 (2010): 62-70.
- Bini, Luca, et al. "Two‐dimensional electrophoretic patterns of acute‐phase human serum proteins in the course of bacterial and viral diseases." Electrophoresis 17.3 (1996): 612-616.
- Yap, Te-Lu, et al. "Salivary biomarker for acute appendicitis in children: a pilot study." Pediatric Surgery International 36 (2020): 621-627.
- Costa, F., et al. "Role of faecal calprotectin as non-invasive marker of intestinal inflammation." Digestive and Liver Disease 35.9 (2003): 642-647.
- Røseth, A. G., E. Aadland, and K. Grzyb. "Normalization of faecal calprotectin: a predictor of mucosal healing in patients with inflammatory bowel disease." Scandinavian journal of gastroenterology 39.10 (2004): 1017-1020.
- Frosch, Michael, et al. "Myeloid‐related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in periarticular‐onset juvenile rheumatoid arthritis." Arthritis & Rheumatism: Official Journal of the American College of Rheumatology 43.3 (2000): 628-637.
- Ambe, Peter C., et al. "Calprotectin could be a potential biomarker for acute appendicitis." Journal of translational medicine 14 (2016): 1-5.
- Míguez, Concepción, et al. "Evaluation of proadrenomedullin as a diagnostic or prognostic biomarker of acute appendicitis in children." The American Journal of Emergency Medicine 34.12 (2016): 2298-2305.
- Ambe, Peter C., et al. "Calprotectin could be a potential biomarker for acute appendicitis." Journal of translational medicine 14 (2016): 1-5.
- Sardà Sánchez, Marta, et al. "Pro-adrenomedullin usefulness in the management of children with community-acquired pneumonia, a preliminar prospective observational study." BMC research notes 5 (2012): 1-5.
- Suberviola, Borja, et al. "Prognostic value of proadrenomedullin in severe sepsis and septic shock patients with community-acquired pneumonia." Swiss Medical Weekly 142.1112 (2012): w13542-w13542.
- Weikert, Cornelia, et al. "Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke." Circulation 118.24 (2008): 2555-2562.
- Fisher, Eva, et al. "Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study." Circulation: Cardiovascular Genetics 2.6 (2009): 607-613.
- Güney, Cengiz, and Abuzer Coskun. "Can fetuin-A, CRP, and WBC levels be predictive values in the diagnosis of acute appendicitis in children with abdominal pain?." Healthcare. Vol. 7. No. 4. MDPI, 2019.
- Bakal, Unal, et al. "Serum, saliva, and urine irisin with and without acute appendicitis and abdominal pain." Biochemistry Insights 9 (2016): BCI-S39671.
- Sipra, Muhammad Afzal, et al. "The predictive value of neutrophil-to-lymphocyte ratio to diagnose acute appendicitis and grade its severity." Journal of Pediatric and Adolescent Surgery 2.1 (2021): 19-23.
- Akyuz, Muhammet, et al. "Predictive value of neutrophil/lymphocyte ratios in the diagnosis of acute appendicitis." Bakırköy Tıp Dergisi 16.1 (2020).
- Halaseh, Sattam A., et al. "Single-center retrospective analysis of neutrophil, monocyte, and platelet to lymphocyte ratios as predictors of complicated appendicitis." Cureus 14.9 (2022).
- Ribeiro, Ana Matos, et al. "Inflammatory parameters as predictive factors for complicated appendicitis: A retrospective cohort study." Annals of Medicine and Surgery 74 (2022): 103266.
- Yilmaz, Banu Karakus, and Yahya Ayhan Acar. "Investigation of the diagnostic value of neutrophil to lymphocyte ratio in pediatric appendicitis cases." Iranian Journal of Pediatrics 27.3 (2017).
- Pogorelić, Zenon, et al. "Hyponatremia as a predictor of perforated acute appendicitis in pediatric population: A prospective study." Journal of pediatric surgery 56.10 (2021): 1816-1821.
-Feng, Wei, et al. "A clinical prediction model for complicated appendicitis in children younger than five years of age." BMC pediatrics 20 (2020): 1-9.
-Şahbaz, Nuri Alper, et al. "The clinical value of leucocyte count and neutrophil percentage in diagnosing uncomplicated (simple) appendicitis and predicting complicated appendicitis." Turkish Journal of Trauma and Emergency Surgery 20.6 (2014): 423-426.
-Pham, Xuan-Binh D., et al. "Factors predictive of complicated appendicitis in children." Journal of Surgical Research 206.1 (2016): 62-66.
-Giri, Niraj. "The Role of Neutrophil Lymphocyte Ratio in Predicting Acute Appendicitis in Adult." Nepal Journal of Multidisciplinary Research 5.1 (2022): 1-13.
-Howell, Erin C., Emily D. Dubina, and Steven L. Lee. "Perforation risk in pediatric appendicitis: assessment and management." Pediatric health, medicine and therapeutics (2018): 135-145.
- Bălănescu, Laura, et al. "Predictors of complicated appendicitis with evolution to appendicular peritonitis in pediatric patients." Medicina 59.1 (2022): 21.
- Gosain, Ankush, Regan F. Williams, and Martin L. Blakely. "Distinguishing acute from ruptured appendicitis preoperatively in the pediatric patient." Advances in Surgery 44.1 (2010): 73-85.
- Bălănescu, Laura, et al. "Predictors of complicated appendicitis with evolution to appendicular peritonitis in pediatric patients." Medicina 59.1 (2022): 21.
- Sack, Ulrich, et al. "Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children." BMC surgery 6 (2006): 1-8.
- Giannis, Dimitrios, Evangelia Matenoglou, and Dimitrios Moris. "Hyponatremia as a marker of complicated appendicitis: A systematic review." The Surgeon 18.5 (2020): 295-304.
- Prasetya, Dedi. "Accuracy of neutrophil lymphocyte ratio for diagnosis of acute appendicitis in children: A diagnostic study." Annals of Medicine and Surgery 48 (2019): 35-38.
- Sipra, Muhammad Afzal, et al. "The predictive value of neutrophil-to-lymphocyte ratio to diagnose acute appendicitis and grade its severity." Journal of Pediatric and Adolescent Surgery 2.1 (2021): 19-23.
- Daldal, Emin, and Hasan Dagmura. "The correlation between complete blood count parameters and appendix diameter for the diagnosis of acute appendicitis." Healthcare. Vol. 8. No. 1. MDPI, 2020.
- Reddan, Tristan, et al. "Ultrasound of paediatric appendicitis and its secondary sonographic signs: providing a more meaningful finding." Journal of medical radiation sciences 63.1 (2016): 59-66.
- Quigley, Alan J., and Samuel Stafrace. "Ultrasound assessment of acute appendicitis in paediatric patients: methodology and pictorial overview of findings seen." Insights into imaging 4 (2013): 741-751.
- Lycopoulou, Lilia, et al. "Serum amyloid A protein levels as a possible aid in the diagnosis of acute appendicitis in children." Clinical Chemistry and Laboratory Medicine (CCLM) 43.1 (2005): 49-53.
- Fest, Jesse, et al. "The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study." European journal of epidemiology 34 (2019): 463-470.
- Kumarasamy, Chellan, et al. "Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer—A protocol for systematic review and meta-analysis." Medicine 98.24 (2019): e14834.
- de Pablo, Raul, et al. "Role of circulating lymphocytes in patients with sepsis." BioMed research international 2014 (2014).
- Rubér, Marie, et al. "Different cytokine profiles in patients with a history of gangrenous or phlegmonous appendicitis." Clinical & Experimental Immunology 143.1 (2006): 117-124.
- Nissen, Matthias, and Ralf-Bodo Tröbs. "The lymphocyte-to-monocyte ratio may distinguish complicated from non-complicated pediatric appendicitis: A retrospective study and literature review." Pediatrics & Neonatology 63.2 (2022): 146-153.
- Hajibandeh, Shahab, et al. "Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: A systematic review and meta-analysis." The American Journal of Surgery 219.1 (2020): 154-163.
- Goodman, David A., Chantelle B. Goodman, and John S. Monk. "Use of the neutrophil: lymphocyte ratio in the diagnosis of appendicitis." The American surgeon 61.3 (1995): 257-259.
- Markar, S. R., et al. "The diagnostic value of neutrophil: lymphocyte ratio in adults with suspected acute appendicitis." Acta Chirurgica Belgica 110.5 (2010): 543-547.
- Shimizu, Takayuki, Mitsuru Ishizuka, and Keiichi Kubota. "A lower neutrophil to lymphocyte ratio is closely associated with catarrhal appendicitis versus severe appendicitis." Surgery today 46 (2016): 84-89.
- Kahramanca, Şahin, et al. "Neutrophil-to-lymphocyte ratio as a predictor of acute appendicitis." Turkish Journal of Trauma and Emergency Surgery 20.1 (2014): 19-22.
- Ishizuka, Mitsuru, Takayuki Shimizu, and Keiichi Kubota. "Neutrophil-to-lymphocyte ratio has a close association with gangrenous appendicitis in patients undergoing appendectomy." International surgery 97.4 (2013): 299-304.
- Khan, A., et al. "Prospective validation of neutrophil-to-lymphocyte ratio as a diagnostic and management adjunct in acute appendicitis." Irish Journal of Medical Science (1971-) 187 (2018): 379-384.
- Virani, Peyman, et al. "Serum Laboratory Biomarkers to Estimate the Probability of Complicated Appendicitis: CRP and LDH." Mathews Journal of Surgery 5.1 (2022): 1-0.
- Mori, Mikito, et al. "Preoperative neutrophil-to-lymphocyte ratio may contribute to the prediction of postoperative infectious complications in patients with acute appendicitis: a retrospective study." BMC surgery 22.1 (2022): 78.
- Nazik, Selçuk, Veli Avci, and Zeynep Küskü Kiraz. "Ischemia-modified albumin and other inflammatory markers in the diagnosis of appendicitis in children." Turkish Journal of Trauma and Emergency Surgery 23.4 (2017): 317-321.
- Pehlivanlı, Faruk, and Oktay Aydin. "Role of platelet to lymphocyte ratio as a biomedical marker for the pre-operative diagnosis of acute appendicitis." Surgical infections 20.8 (2019): 631-636.
- Pehlivanlı, Faruk, and Oktay Aydin. "Role of platelet to lymphocyte ratio as a biomedical marker for the pre-operative diagnosis of acute appendicitis." Surgical infections 20.8 (2019): 631-636.
- Mickiewicz, Beata, et al. "Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit." Critical Care 19 (2015): 1-12.
- Shommu, Nusrat S., et al. "The use of metabolomics and inflammatory mediator profiling provides a novel approach to identifying pediatric appendicitis in the emergency department." Scientific reports 8.1 (2018): 4083.
- Pehlivanlı, Faruk, and Oktay Aydin. "Role of platelet to lymphocyte ratio as a biomedical marker for the pre-operative diagnosis of acute appendicitis." Surgical infections 20.8 (2019): 631-636.
- Filipp, Fabian V. "Opportunities for artificial intelligence in advancing precision medicine." Current genetic medicine reports 7.4 (2019): 208-213.
- Wright, Caroline F., David R. FitzPatrick, and Helen V. Firth. "Paediatric genomics: diagnosing rare disease in children." Nature Reviews Genetics 19.5 (2018): 253-268.
- Brewington, John, and J. P. Clancy. "Diagnostic testing in cystic fibrosis." Clinics in chest medicine 37.1 (2016): 31-46.
- Aartsma-Rus, Annemieke, Ieke B. Ginjaar, and Kate Bushby. "The importance of genetic diagnosis for Duchenne muscular dystrophy." Journal of medical genetics 53.3 (2016): 145-151.
- Crespi, Bernard J., and Tanya L. Procyshyn. "Williams syndrome deletions and duplications: Genetic windows to understanding anxiety, sociality, autism, and schizophrenia." Neuroscience & Biobehavioral Reviews 79 (2017): 14-26.
- Sarsu, Sevgi Büyükbeşe, et al. "Polymorphisms in the IL-6 and IL-6R receptor genes as new diagnostic biomarkers of acute appendicitis: a study on two candidate genes in pediatric patients with acute appendicitis." Italian Journal of Pediatrics 41 (2015): 1-5.
- Orlova, Ekaterina, et al. "Genetic association and differential expression of PITX2 with acute appendicitis." Human genetics 138 (2019): 37-47.
- Chambers, Daniel C., et al. "Transcriptomics and single‐cell RNA‐sequencing." Respirology 24.1 (2019): 29-36.
- Chawla, Lakhmir S., et al. "Acute appendicitis: transcript profiling of blood identifies promising biomarkers and potential underlying processes." BMC Medical Genomics 9 (2016): 1-11.
- Muenzer, Jared T., et al. "Evidence for a novel blood RNA diagnostic for pediatric appendicitis: the riboleukogram." Pediatric emergency care 26.5 (2010): 333-338.
- Zojaji, Homayoun, et al. "Metabolic analysis of acute appendicitis by using system biology approach." Gastroenterology and Hepatology from Bed to Bench 11.Suppl 1 (2018): S92.
- Naqvi, S. Ali, et al. "Cytokines and chemokines in pediatric appendicitis: a multiplex analysis of inflammatory protein mediators." Mediators of inflammation 2019 (2019).
- Yu, Mengjie, et al. "Diagnosis of acute pediatric appendicitis from children with inflammatory diseases by combination of metabolic markers and inflammatory response variables." Clinical Chemistry and Laboratory Medicine (CCLM) 56.6 (2018): 1001-1010.
- Shommu, Nusrat S., et al. "Metabolomic and inflammatory mediator based biomarker profiling as a potential novel method to aid pediatric appendicitis identification." PLoS One 13.3 (2018): e0193563.
- Hodge, Sarah VL, et al. "Novel molecular biomarkers and diagnosis of acute appendicitis in children." Biomarkers in Medicine 15.12 (2021): 1055-1065.
- Salek, Reza M., et al. "COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access." Metabolomics 11 (2015): 1587-1597.
- McGrath, Scott, and Dario Ghersi. "Building towards precision medicine: empowering medical professionals for the next revolution." BMC medical genomics 9 (2016): 1-6.
- Schneider, John E., et al. "Cost impact model of a novel multi-mRNA host response assay for diagnosis and risk assessment of acute respiratory tract infections and sepsis in the emergency department." Journal of health economics and outcomes research 7.1 (2020): 24.
- Deng, Lu, et al. "Development and validation of a high-throughput mass spectrometry based urine metabolomic test for the detection of colonic adenomatous polyps." Metabolites 7.3 (2017): 32.
- Barichello, Scott, et al. "Comparative effectiveness and cost-effectiveness analysis of a urine metabolomics test vs. alternative colorectal cancer screening strategies." International Journal of Colorectal Disease 34 (2019): 1953-1962.
- Hodge, Sarah VL, et al. "Novel molecular biomarkers and diagnosis of acute appendicitis in children." Biomarkers in Medicine 15.12 (2021): 105
DOI: http://dx.doi.org/10.52155/ijpsat.v44.1.6143
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