Central Corneal Thickness Comparison between Primary Open-Angle Glaucoma Patients and Healthy Controls

Salma Mohammed Elsharif, Mariam Mohamed B. Gebril, Hanan Alsagheer

Abstract


Glaucoma is a progressive eye disease characterized by optic nerve damage and visual field loss, often associated with elevated intraocular pressure (IOP). Central corneal thickness (CCT) has been identified as a potential factor influencing the measurement and management of IOP. Several studies have investigated the relationship between CCT and glaucoma, highlighting its importance in the diagnosis and management of the disease. Aim: to assess whether there are any significant differences in CCT measurements between open-angle glaucoma patients and normal patients. Material and methods: observational a cross-sectional design to compare CCT between normal individuals and POAG patients, we examined a sample consisting of 20 individuals in the control group and 20 individuals diagnosed with primary open-angle glaucoma (POAG). Corneal pachymetry and a complete eye examination were performed on all patients. Result: In the control group, the average central corneal thickness (CCT) was measured to be 538 µm. On the other hand, in the primary open-angle glaucoma group, the mean CCT was found to be 536 µm, and there was no statistically significant difference in central corneal thickness (CCT) between the primary open-angle glaucoma (POAG) group and the control group (P = 0.8). conclusion: No significant disparity in central corneal thickness (CCT) was observed between individuals diagnosed with primary open-angle glaucoma and normal subjects in our study.


Keywords


central corneal thickness; norma patient; primary open-angle glaucoma; pachymetry; comparative study.

Full Text:

PDF

References


Kingman S. Glaucoma is second leading cause of blindness globally. Bull World Health Organ. 2004;82(11):887-8.

Prum BE, Jr., Lim MC, Mansberger SL, Stein JD, Moroi SE, Gedde SJ, et al. Primary Open-Angle Glaucoma Suspect Preferred Practice Pattern(®) Guidelines. Ophthalmology. 2016;123(1):P112-51.

Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121(11):2081-90.

Mitchell P, Smith W, Attebo K, Healey PR. Prevalence of open-angle glaucoma in Australia. The Blue Mountains Eye Study. Ophthalmology. 1996;103(10):1661-9.

Varma R, Ying-Lai M, Francis BA, Nguyen BB, Deneen J, Wilson MR, et al. Prevalence of open-angle glaucoma and ocular hypertension in Latinos: the Los Angeles Latino Eye Study. Ophthalmology. 2004;111(8):1439-48.

Tielsch JM, Sommer A, Katz J, Royall RM, Quigley HA, Javitt J. Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey. Jama. 1991;266(3):369-74.

Burr JM, Mowatt G, Hernández R, Siddiqui MA, Cook J, Lourenco T, et al. The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation. Health Technol Assess. 2007;11(41):iii-iv, ix-x, 1-190.

Doughty MJ, Zaman ML. Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol. 2000;44(5):367-408.

Sng CC, Ang M, Barton K. Central corneal thickness in glaucoma. Curr Opin Ophthalmol. 2017;28(2):120-6.

Goldmann H, Schmidt T. [Applanation tonometry]. Ophthalmologica. 1957;134(4):221-42.

Wolfs RC, Klaver CC, Vingerling JR, Grobbee DE, Hofman A, de Jong PT. Distribution of central corneal thickness and its association with intraocular pressure: The Rotterdam Study. Am J Ophthalmol. 1997;123(6):767-72.

Shih CY, Zivin JSG, Trokel SL, Tsai JC. Clinical Significance of Central Corneal Thickness in the Managementof Glaucoma. Archives of Ophthalmology. 2004;122(9):1270-5.

Natarajan M, Das K, Jeganathan J. Comparison of central corneal thickness of primary open angle glaucoma patients with normal controls in South India. Oman J Ophthalmol. 2013;6(1):33-6.

Whitacre MM, Stein RA, Hassanein K. The effect of corneal thickness on applanation tonometry. Am J Ophthalmol. 1993;115(5):592-6.

Browning AC, Bhan A, Rotchford AP, Shah S, Dua HS. The effect of corneal thickness on intraocular pressure measurement in patients with corneal pathology. Br J Ophthalmol. 2004;88(11):1395-9.

Ehlers N, Bramsen T, Sperling S. Applanation tonometry and central corneal thickness. Acta Ophthalmol (Copenh). 1975;53(1):34-43.

Aghaian E, Choe JE, Lin S, Stamper RL. Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic. Ophthalmology. 2004;111(12):2211-9.

Sanchis-Gimeno J.A. AL, Rahhal S.M., Martinez-Soriano F. Gender differences in corneal thickness values. European journal for anatomy 2015;8(1136-4890):67-70.

Chebil A, Choura R, Falfoul Y, Fekih O, El Matri L. Central corneal thickness in a healthy Tunisian population. Tunis Med. 2021;99(2):221-4.




DOI: http://dx.doi.org/10.52155/ijpsat.v43.1.6030

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Hanan Alsagheer

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.