Prevalence And Prognosis Of Candidiasis Among Covid-19 Patients: Data From ICU Department

Tamar DIDBARIDZE, L Ratiani, N Labadze, T Maziashvili

Abstract


Yeast species belonging to the Candida genus, including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Candida krusei, are the most prevalent fungal species inhabiting various mucosal surfaces, such as the skin and the respiratory, digestive, and urinary tracts [1]. Although being commensal within the human host, Candida species are equipped with virulence attributes, enabling them to invade when opportunities arise and cause various infections in humans, especially when the immune system is impaired.

 We retrospectively studied total lymphocytes count and   Candida infection in 142 patients   who were admitted to TSMU The First university Clinic Intensive care unit department between 14.10.20 – 02.02.21 . Among  142 patients Candida  spp  were isolated in 15,4%(22/142) patients. In all this patients  total lymphocytes count were low.  Candidemia was  not dectected.  Candiduria was observed in 2 patients(9%, 2/22). Our data is close to the  White, P.L. et al studies from UK which have reported 12.6%(17/135) of Candidiasis.


Keywords


Candidiasis, covid-19, ICU department, lymphophenia, treatment.

Full Text:

PDF

References


Hallen-Adams, H.E.; Suhr, M.J. Fungi in the healthy human gastrointestinal tract. Virulence 2017, 8, 352–358.

Rolling, T.; Hohl, T.M.; Zhai, B. Minority report: The intestinal mycobiota in systemic infections.Curr. Opin. Microbiol. 2020, 56, 1–6

Azoulay, E.; Timsit, J.-F.; Ta et, M.; De Lassence, A.; Darmon, M.; Zahar, J.-R.; Adrie, C.; Garrouste-Orgeas, M.;Cohen, Y.; Mourvillier, B.; et al. Candida Colonization of the Respiratory Tract and Subsequent Pseudomonas Ventilator-Associated Pneumonia. Chest 2006, 129, 110–117

Lortholary, O.; The French Mycosis Study Group; Renaudat, C.; Sitbon, K.; Madec, Y.; Denoeud-Ndam, L.;Wol, M.; Fontanet, A.; Bretagne, S.; Dromer, F. Worrisome trends in incidence and mortality of candidemialin intensive care units (Paris area, 2002–2010). Intensiv. Care Med. 2014, 40, 1303–1312.

Kullberg, B.J.; Arendrup, M.C. Invasive Candidiasis. New Engl. J. Med. 2015, 373, 1445–1456

Marra, A.R.; Camargo, L.F.A.; Pignatari, A.C.C.; Sukiennik, T.; Behar, P.R.P.; Medeiros, E.A.S.; Ribeiro, J.;Girão, E.; Correa, L.; Guerra, C.; et al. Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysisof 2,563 Cases from a Prospective Nationwide Surveillance Study. J. Clin. Microbiol. 2011, 49, 1866–1871.

Zheng, M.; Gao, Y.;Wang, G.; Song, G.; Liu, S.; Sun, D.; Xu, Y.; Tian, Z. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell. Mol. Immunol. 2020, 17, 533–535

Pittiruti, M.; Pinelli, F. Recommendations for the use of vascular access in the COVID-19 patients: An Italian perspective. Crit. Care 2020, 24, 1–3.

A Chow, N.; Gade, L.; Tsay, S.V.; Forsberg, K.; A Greenko, J.; Southwick, K.L.; Barrett, P.M.; Kerins, J.L.;Lockhart, S.R.; Chiller, T.M.; et al. Multiple introductions and subsequent transmission of multidrug-resistant Candida auris in the USA: A molecular epidemiological survey. Lancet Infect. Dis. 2018, 18, 1377–1384.

Eyre, D.W.; Sheppard, A.E.; Madder, H.; Moir, I.; Moroney, R.; Quan, T.P.; Griths, D.; George, S.; Butcher, L.;Morgan, M.; et al. A Candida auris Outbreak and Its Control in an Intensive Care Setting. New Engl. J. Med. 2018, 379, 1322–1331

Chowdhary, A.; Sharma, A. The lurking scourge of multidrug resistant Candida auris in times of COVID-19 pandemic. J. Glob. Antimicrob. Resist. 2020, 22, 175–176.

Tóth, R.; Nosek, J.; Mora-Montes, H.M.; Gabaldon, T.; Bliss, J.M.; Nosanchuk, J.D.; Turner, S.A.; Butler, G.;Vágvölgyi, C.; Gácser, A. Candida parapsilosis: From Genes to the Bedside. Clin. Microbiol. Rev. 2019, 32.

Antinori, S.; Bonazzetti, C.; Gubertini, G.; Capetti, A.; Pagani, C.; Morena, V.; Rimoldi, S.; Galimberti, L.;Sarzi-Puttini, P.; Ridolfo, A.L. Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia:An increased risk for candidemia? Autoiimun. Rev. 2020, 19, 102564

White, P.L.; Dhillon ,R.; Cordey, A.; Hughes, H.; Faggian, F.; Soni, S.; Pandey, M.; Whitaker, H.; May, A.;Morgan, M.; et al. A national strategy to diagnose COVID-19 associated invasive fungal disease in the ICU.Clin. Infect. Dis. 2020.

Chen, N.; Zhou, M.; Dong, X.; Qu, J.; Gong, F.; Han, Y.; Qiu, Y.;Wang, J.; Liu, Y.;Wei, Y.; et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 2020, 395, 507–513

Salehi, M.; Ahmadikia, K.; Mahmoudi, S.; Kalantari, S.; Siahkali, S.J.; Izadi, A.; Kord, M.; Manshadi, S.A.D.;Seifi, A.; Ghiasvand, F.; et al. Oropharyngeal candidiasis in hospitalized COVID-19 Patients from Iran: Species identification and antifungal susceptibility pattern. Mycoses 2020




DOI: http://dx.doi.org/10.52155/ijpsat.v26.1.2940

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Tamar DIDBARIDZE, L Ratiani, N Labadze, T Maziashvili

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.