In Review: Chemical Compound Content of Uncaria Plant and Its Pharmacological Effects

Zikkra Audina, Mildawati Mildawati

Abstract


Species in the Uncaria have significant therapeutic potential for a variety of health problems, including neurodegenerative disorders, depression and conditions associated with osmotic stress. Their active compounds, such as alkaloids, flavonoids, phenolics, and terpenoids, have been extensively studied for their anti-inflammatory, antioxidant and immunomodulatory effects. In particular, Uncaria rhynchophylla has been shown to have potent anti-inflammatory, antimicrobial and immunomodulatory effects. This article aims to review research related to the chemical compounds and pharmacological effects of Uncaria plants. The method used in writing this review article involved a systematic search in various digital databases, including ScienceDirect. The search results show that the use of Uncaria as a medicinal ingredient continues to be developed, focusing on new extracts and drug formulas. Uncaria plants contain various chemical compounds, such as triterpenes, glycosides, polyphenols, flavonoids and alkaloids, each with pharmacological potential. Studies have shown that compounds in Uncaria have neuroprotective, antioxidant, immunomodulatory and anti-inflammatory effects. With the identification and characterization of critical compounds in Uncaria, there are great opportunities for developing effective herbal therapies. This article concludes that further research and development of Uncaria based formulations are needed to maximize their therapeutic potential and provide more natural and effective treatment alternatives.


Keywords


antioxidant, chemical compounds; herbal therapy; immunomodulatory; pharmacological effects

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DOI: http://dx.doi.org/10.52155/ijpsat.v45.2.6282

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