Effect of Extract Bitter (Andrographis Paniculata Nees.) of The Uterus Histological Mice (Mus Musculus L.)

Abstract

Indonesia has a wide variety of germs that are used as a source of traditional medicines that are widely used by the community. One of the commonly used plants is bitter plants. Bitter plants have many specialty but bitter plants also have side effects that can cause undesirable effects if used in large quantities, especially in pregnant women because Bitter has chemical compounds that act as antifertility. Pursuant to this matter done research to know influence of  Bitter extract to histologis uterus mouse. This research was an experimental research with complete randomized design (RAL), 4 treatments and 6 replications. The treatment used was control, dose 0,2 g / kgbb, 0,4 g / kg bb, 0,6 g / kg bw done by gavage for 12 days. Parameters observed were uterine weight, long cornua, thick endometrium, myometrium, perimetrium damage and abnormalities in uterine mice. The uterus is made of micro anatomical sedation with hematoxylin-eosin (HE) staining. Data were analyzed by variance (ANOVA) significant level 0,05 and continued with BNT test. The results showed that the Bitter extract had no effect on the weight, length of cornua, thickness, myometrium, perimetrium but effect on endometrial thickness. It can be concluded that Bitter extract can affect fertility in females.