Neonatal Herpes Simplex Virus Infections: Diagnosis, Treatment, and Prevention

Maged Naser, Mohamed M. Naser, Lamia H. Shehata

Abstract


Neonatal herpes simplex infection (HSV) is a ruinous disease in infants, related with broad morbidity and mortality. The utilization of PCR for HSV identification of infected new born and acyclovir for treatment has considerably further developed Acyclovir anticipation for affected new borns. The resulting utilization of suppressive therapy with oral acyclovir following completion of parenteral treatment of acute disease has also worked on the long term prognosis for these new borns.

This review will discuss the study of disease transmission, risk factors and routes of acquisition, clinical presentation, and assessment of neonates thought to have the infection, and treatment of proven neonatal HSV disease.


Keywords


Herpes Simplex Virus (HSV); Neonate; Pregnancy; Acyclovir.

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References


Akhtar, Jihan, and Deepak Shukla. "Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry." The FEBS journal 276.24 (2009): 7228-7236.

Roizman, Bernard, and Richard J. Whitley. "An inquiry into the molecular basis of HSV latency and reactivation." Annual review of microbiology 67 (2013): 355-374.

Mocarski, Edward S., and Bernard Roizman. "Structure and role of the herpes simplex virus DNA termini in inversion, circularization and generation of virion DNA." Cell 31.1 (1982): 89-97.

Buchman, Timothy G., et al. "Restriction endonuclease fingerprinting of herpes simplex virus DNA: a novel epidemiological tool applied to a nosocomial outbreak." Journal of Infectious Diseases 138.4 (1978): 488-498.

Umene, Kenichi, and Takashi Kawana. "Divergence of reiterated sequences in a series of genital isolates of herpes simplex virus type 1 from individual patients." Journal of general virology 84.4 (2003): 917-923.

Steiner, Israel. "Herpes simplex virus encephalitis: new infection or reactivation?" Current opinion in neurology 24.3 (2011): 268-274.

Smith, Jennifer S., and N. Jamie Robinson. "Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review." The Journal of infectious diseases186.Supplement_1 (2002): S3-S28.

Nahmias, ANDRÉ J., FRANCIS K. Lee, and S. U. S. A. Beckman-Nahmias. "Sero-epidemiological and-sociological patterns of herpes simplex virus infection in the world." Scand J Infect Dis Suppl 69 (1990): 19-36.

Tunbäck, Petra, et al. "Prevalence of herpes simplex virus antibodies in childhood and adolescence: a cross-sectional study." Scandinavian journal of infectious diseases 35.8 (2003): 498-502.

Belova, Anastasiya V., et al. "Genital herpes and pregnancy." VF Snegirev Archives of Obstetrics and Gynaecology 4.3 (2017): 124-130.

Corey, Lawrence, et al. "The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics." JAIDS Journal of Acquired Immune Deficiency Syndromes 35.5 (2004): 435-445.

Fleming, Douglas T., et al. "Herpes simplex virus type 2 in the United States, 1976 to 1994." New England Journal of Medicine 337.16 (1997): 1105-1111.

Xu, Fujie, et al. "Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States." Jama 296.8 (2006): 964-973.

Patton, Monica E., et al. "Seroprevalence of herpes simplex virus types 1 and 2 among pregnant women and sexually active, nonpregnant women in the United States." Clinical Infectious Diseases 67.10 (2018): 1535-1542.

Bernstein, David I., et al. "Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women." Clinical infectious diseases 56.3 (2013): 344-351.

Roberts, Craig M., John R. Pfister, and Scott J. Spear. "Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students." Sexually transmitted diseases 30.10 (2003): 797-800.

Slutsker, Jennifer Sanderson, and Julia A. Schillinger. "Assessing the burden of infant deaths due to herpes simplex virus, human immunodeficiency virus, and congenital syphilis: United States, 1995 to 2017." Sexually Transmitted Diseases48.8 Suppl (2021): S4.

Stephenson-Famy, Alyssa, and Carolyn Gardella. "Herpes simplex virus infection during pregnancy." Obstetrics and Gynaecology Clinics 41.4 (2014): 601-614.

Kulhanjian, Julie A., et al. "Identification of women at unsuspected risk of primary infection with herpes simplex virus type 2 during pregnancy." New England Journal of Medicine326.14 (1992): 916-920.

Kucera, Pavel, et al. "Seroepidemiology of herpes simplex virus type 1 and 2 in pregnant women in Switzerland: an obstetric clinic based study." European Journal of Obstetrics & Gynaecology and Reproductive Biology 160.1 (2012): 13-17.

Sheffield, Jeanne S., et al. "Valacyclovir prophylaxis to prevent recurrent herpes at delivery: a randomized clinical trial." Obstetrics & Gynaecology 108.1 (2006): 141-147.

Watts, D. Heather, et al. "A double-blind, randomized, placebo-controlled trial of acyclovir in late pregnancy for the reduction of herpes simplex virus shedding and caesarean delivery." American journal of obstetrics and gynaecology 188.3 (2003): 836-843.

Brown, Zane A., et al. "The acquisition of herpes simplex virus during pregnancy." New England Journal of Medicine 337.8 (1997): 509-516.

Yeager, Anne S., and Ann M. Arvin. "Reasons for the absence of a history of recurrent genital infections in mothers of neonates infected with herpes simplex virus." Pediatrics 73.2 (1984): 188-193.

Whitley, Richard J. "Herpes simplex virus infections of the central nervous system." Neuroinflammation and Neurodegeneration (2014): 263-290.

Whitley, Richard J., et al. "Changing presentation of herpes simplex virus infection in neonates." Journal of Infectious Diseases 158.1 (1988): 109-116.

Brown, Zane A., et al. "Effect of serologic status and caesarean delivery on transmission rates of herpes simplex virus from mother to infant." Jama 289.2 (2003): 203-209.

Kropp, Rhonda Y., et al. "Neonatal herpes simplex virus infections in Canada: results of a 3-year national prospective study." Pediatrics 117.6 (2006): 1955-1962.

Jones, Cheryl A., Camille Raynes-Greenow, and David Isaacs. "Population-based surveillance of neonatal herpes simplex virus infection in Australia, 1997–2011." Clinical infectious diseases 59.4 (2014): 525-531.

Smith, Jennifer S., and N. Jamie Robinson. "Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review." The Journal of infectious diseases186.Supplement_1 (2002): S3-S28.

Malkin, Jean-Elie. "Epidemiology of genital herpes simplex virus infection in developed countries." Herpes: the journal of the IHMF 11 (2004): 2A-23A.

James, Scott H., and David W. Kimberlin. "Neonatal herpes simplex virus infection." Infectious Disease Clinics 29.3 (2015): 391-400.

Berntsson, Matilda, et al. "Decreasing prevalence of herpes simplex virus-2 antibodies in selected groups of women in Sweden." Acta dermato-venereologica 89.6 (2009).

Mertz, Gregory J., Susan L. Rosenthal, and Lawrence R. Stanberry. "Is herpes simplex virus type 1 (HSV-1) now more common than HSV-2 in first episodes of genital herpes?" Sexually transmitted diseases 30.10 (2003): 801-802.

James, Scott H., and David W. Kimberlin. "Neonatal herpes simplex virus infection." Infectious Disease Clinics 29.3 (2015): 391-400.

Kimberlin, David W. "The scarlet H." The Journal of infectious diseases 209.3 (2014): 315-317.

Whitley, Richard J. "Herpes simplex virus infections of the central nervous system." Drugs 42.3 (1991): 406-427.

Brown, Zane A., et al. "Effect of serologic status and caesarean delivery on transmission rates of herpes simplex virus from mother to infant." Jama 289.2 (2003): 203-209.

Baker, David A. "Consequences of herpes simplex virus in pregnancy and their prevention." Current opinion in infectious diseases 20.1 (2007): 73-76.

Watts, D. Heather, et al. "A double-blind, randomized, placebo-controlled trial of acyclovir in late pregnancy for the reduction of herpes simplex virus shedding and caesarean delivery." American journal of obstetrics and gynaecology 188.3 (2003): 836-843.

Brown, Zane A., et al. "Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labour." New England Journal of Medicine 324.18 (1991): 1247-1252.

Arvin, Ann M., et al. "Failure of antepartum maternal cultures to predict the infant's risk of exposure to herpes simplex virus at delivery." New England Journal of Medicine 315.13 (1986): 796-800.

Pinninti, Swetha G., and David W. Kimberlin. "Maternal and neonatal herpes simplex virus infections." American journal of perinatology 30.02 (2013): 113-120.

Sullender, Wayne M., et al. "Type-specific antibodies to herpes simplex virus type 2 (HSV-2) glycoprotein G in pregnant women, infants exposed to maternal HSV-2 infection at delivery, and infants with neonatal herpes." Journal of Infectious Diseases 157.1 (1988): 164-165.

Tookey, Pat, and Catherine S. Peckham. "Neonatal herpes simplex virus infection in the British Isles." Paediatric and perinatal epidemiology 10.4 (1996): 432-442.

Pascual, A., et al. "Neonatal herpes simplex virus infections in Switzerland: results of a 6-year national prospective surveillance study." Clinical microbiology and infection 17.12 (2011): 1907-1910.

De Jong, E. P., et al. "Is routine TORCH screening warranted in neonates with lenticulostriate vasculopathy?" Neonatology97.3 (2010): 274-278.

Schillinger, Julia A., and Susan Blank. "Julia A. Schillinger, MD, MSc." (2013).

Samies, Nicole L., Scott H. James, and David W. Kimberlin. "Neonatal Herpes Simplex Virus Disease: Updates and Continued Challenges." Clinics in Perinatology 48.2 (2021): 263-274.

Brown, Zane A., Anna Wald, and Lawrence Corey. "Caesarean delivery and risk of herpes simplex virus infection." Jama289.17 (2003): 2208-2209.

Corey, Lawrence, and Anna Wald. "Maternal and neonatal herpes simplex virus infections." New England Journal of Medicine 361.14 (2009): 1376-1385.

Pinninti, Swetha G., and David W. Kimberlin. "Neonatal herpes simplex virus infections." Seminars in perinatology. Vol. 42. No. 3. WB Saunders, 2018.

Pittet, Laure F., and Nigel Curtis. "Postnatal Exposure to Herpes Simplex Virus: To Treat or Not to Treat?" The Pediatric Infectious Disease Journal 40.5S (2021): S16-S21.

Patel, Chaya D., et al. "Maternal immunization confers protection against neonatal herpes simplex mortality and behavioural morbidity." Science translational medicine 11.487 (2019): eaau6039.

Samies, Nicole L., and Scott H. James. "Prevention and treatment of neonatal herpes simplex virus infection." Antiviral research 176 (2020): 104721.

Hill, James B., et al. "Intrapartum fetal surveillance: review of three national guidelines." American journal of perinatology29.07 (2012): 539-550.

Nahmias, AndréJ, et al. "Perinatal risk associated with maternal genital herpes simplex virus infection." American journal of obstetrics and gynaecology 110.6 (1971): 825-837.

Anzivino, Elena, et al. "Herpes simplex virus infection in pregnancy and in neonate: status of art of epidemiology, diagnosis, therapy and prevention." Virology journal 6.1 (2009): 1-11.

Pinninti, Swetha G., and David W. Kimberlin. "Preventing herpes simplex virus in the new born." Clinics in perinatology41.4 (2014): 945-955.

Whitley, R. J. "Neonatal herpes simplex virus infections." Journal of medical virology 41. S1 (1993): 13-21.

Whitley, Richard, et al. "A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection." New England Journal of Medicine 324.7 (1991): 444-449.

Whitley, Richard, et al. "Predictors of morbidity and mortality in neonates with herpes simplex virus infections." New England Journal of Medicine 324.7 (1991): 450-454.

Kimberlin, David W., et al. "Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections." Pediatrics 108.2 (2001): 230-238.

James, Scott H., and David W. Kimberlin. "Neonatal herpes simplex virus infection." Infectious Disease Clinics 29.3 (2015): 391-400.

Pittet, Laure F., and Nigel Curtis. "Postnatal Exposure to Herpes Simplex Virus: To Treat or Not to Treat?" The Pediatric Infectious Disease Journal 40.5S (2021): S16-S21.

Rellosa, Neil. "İnfectious etiologies of cerebral palsy." Cerebral Palsy (2020): 45-54.

Corey, Lawrence, and Anna Wald. "Maternal and neonatal herpes simplex virus infections." New England Journal of Medicine 361.14 (2009): 1376-1385.

Kimberlin, David W., et al. "Application of the polymerase chain reaction to the diagnosis and management of neonatal herpes simplex virus disease." Journal of Infectious Diseases174.6 (1996): 1162-1167.

Kimura, Hiroshi, et al. "Detection of viral DNA in neonatal herpes simplex virus infections: frequent and prolonged presence in serum and cerebrospinal fluid." Journal of Infectious Diseases 164.2 (1991): 289-293.

Malm G, Forsgren M. Neonatal herpes simplex virus infections: HSV DNA in cerebrospinal fluid and serum. Arch Dis Child Fetal Neonatal Ed. 1999;81:F24–F29.

James, Scott H., and David W. Kimberlin. "Quantitative herpes simplex virus concentrations in neonatal infection." The Journal of Pediatrics 166.4 (2015): 793-795.

James, Scott H., and David W. Kimberlin. "Quantitative herpes simplex virus concentrations in neonatal infection." The Journal of Pediatrics 166.4 (2015): 793-795.

Arend-Trujillo, Monica, and Lauren Dhugga. "Neonatal herpes simplex virus infection: maternal risk stratification and management of at-risk neonates." Infant 18.1 (2022).

UK Health Security Agency. Varicella: the green book, chapter 34. 2019 online at: www.gov.uk/ government/publications/varicella-the-green-b

Ramgopal, Sriram, Paria M. Wilson, and Todd A. Florin. "Diagnosis and management of neonatal herpes simplex infection in the emergency department." Pediatric emergency care 36.4 (2020): 196-202.

Hanna, Mina H., David J. Askenazi, and David T. Selewski. "Drug induced acute kidney injury in neonates." Current opinion in pediatrics 28.2 (2016): 180.

Kimberlin, David W., et al. "Oral acyclovir suppression and neurodevelopment after neonatal herpes." New England Journal of Medicine 365.14 (2011): 1284-1292.

Kakiuchi, Satsuki, et al. "Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain." Journal of clinical microbiology 51.1 (2013): 356-359.

Bacon, Teresa H., et al. "Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy." Clinical microbiology reviews 16.1 (2003): 114-128.

Kakiuchi, Satsuki, et al. "Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain." Journal of clinical microbiology 51.1 (2013): 356-359.

MAAKS, DAWN LEE GARZON. "Principles of developmental management of children." Burns' Pediatric Primary Care E-Book (2019): 63.

Chudnovets, Anna, et al. "Role of inflammation in virus pathogenesis during pregnancy." Journal of virology 95.2 (2020): e01381-19.

Roberts, Scott W., et al. "Genital herpes during pregnancy: no lesions, no caesarean." Obstetrics & Gynaecology 85.2 (1995): 261-264.

Rogan, Sarah C., and Richard H. Beigi. "Management of Viral Complications of Pregnancy: Pharmacotherapy to Reduce Vertical Transmission." Obstetrics and Gynaecology Clinics48.1 (2021): 53-74.

Stanberry, Lawrence R., et al. "Glycoprotein-D–adjuvant vaccine to prevent genital herpes." New England Journal of Medicine 347.21 (2002): 1652-1661.

Belshe, Robert B., et al. "Efficacy results of a trial of a herpes simplex vaccine." New England Journal of Medicine 366.1 (2012): 34-43.

Slutsker, Jennifer Sanderson, and Julia A. Schillinger. "Assessing the burden of infant deaths due to herpes simplex virus, human immunodeficiency virus, and congenital syphilis: United States, 1995 to 2017." Sexually Transmitted Diseases48.8 Suppl (2021): S4.




DOI: http://dx.doi.org/10.52155/ijpsat.v32.2.4308

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