The Influence of African Leaf (Vernonia Amygdalina Delile) Extract On Blood Glucose Levels of Diabetic Rats

Veince Benjamin Silahooy, Meillisa Carlen Mainassy, Imanuel B D. Kapelle, Laury M C. Huwae

Abstract


Diabetes mellitus (DM) is a disease associated with lifestyle, especially food consumption. One way to reduce and treat the pathogenesis of diabetes is by providing antioxidants that are proton compounds to reduce the negative effects of ROS. African leaves contain flavonoid compounds, glycosides, saponins, tannins, and triterpenoids / steroids that function as primary antioxidants and scavenger to superoxide anions. The purpose of this research is to know the effect of African Leaves (Vernonia amygdalina Delile) on blood glucose levels of diabetic rats. The results showed that African leaves have an effect on blood glucose levels of diabetic rats. The concentration of African leaf extract which gives effect to the decrease of glucose level is 60%, at 127 mg/dl glucose level.

 

Keywords: African leaves, extraction, diabetes

Keywords


African Leaves; Extraction; Diabetes.

Full Text:

PDF

References


R. C. Ma and P. C. Tong, “Epidemiology of type 2 diabetes,” Textb. Diabetes, vol. 4, pp. 45–68, 2010.

I. A. Van den Oever, H. G. Raterman, M. T. Nurmohamed, and S. Simsek, “Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus,” Mediators Inflamm., vol. 2010, 2010.

A. M. Vincent, J. W. Russell, P. Low, and E. L. Feldman, “Oxidative stress in the pathogenesis of diabetic neuropathy,” Endocr. Rev., vol. 25, no. 4, pp. 612–628, 2004.

B. Vîrgolici et al., “Relation between inflammation and oxidative stress markers in diabetic foot patients,” inflammation, vol. 6, p. 13, 2008.

J. Pokorny, N. Yanishlieva, and M. H. Gordon, Antioxidants in food: practical applications. CRC press, 2001.

A. S. H. Ong, E. Niki, and L. Packer, Nutrition, Lipids, and Desease. AOCS, Press, Champaign, Illinois, 1995.

R. Tsao, “Chemistry and biochemistry of dietary polyphenols,” Nutrients, vol. 2, no. 12, pp. 1231–1246, 2010.

C. Rice-Evans, N. Miller, and G. Paganga, “Antioxidant properties of phenolic compounds,” Trends Plant Sci., vol. 2, no. 4, pp. 152–159, 1997.




DOI: http://dx.doi.org/10.52155/ijpsat.v8.1.367

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 Veince Benjamin Silahooy

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.