Human" C-Reactive Protein (CRP) 1919 A/T" Polymorphism in Patients with Breast Cancer

Zafir Hassan Ghali

Abstract


"C-reactive protein (CRP)" demonstrates essential prognosis in many diseases due to its vital role in inflammation response Breast cancer is the most common cancer in the world and is the second largest among the various types of cancer among women...In this study we aimed to determine the frequency of "SNP   rs1417938 of CRP gene "and investigate this polymorphism in a group breast cancer patients. The most common "CRP 1919 (rs1417938)" was evaluated in 20 patients with breast cancer A allele is a major one in the studied population. This allele is more common in breast cancer patients (1.00). The patients with breast cancer are more likely to own AA genotypes. The individuals with genotype AT or TT have not been detected in the studied groups. These preliminary data can be considered as pilot ones. These data give reason to assume that A is a predisposing allele to breast cancer. 


Keywords


C-reactive protein, polymorphism,breast cancer,genotype

Full Text:

PDF

References


Lunetta C, Lizio A, Maestri E, Sansone VA, Mora G, Miller RG, Appel SH, Chiò A. Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis. JAMA Neurol. 2017; 1;74(6):660-667. doi: 10.1001/jamaneurol.2016.6179.

Maccio, A., Madeddu, C. & Mantovani, G. Adipose tissue as target organ in the treatment of hormone-dependent breast cancer: new therapeutic perspectives. Obes. Rev.2009;10, 660–670 .

Allin K. H., Nordestgaard B. G. Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer. Critical Reviews in Clinical Laboratory Sciences. 2011;48(4):155–170. doi: 10.3109/10408363.2011.599831.

Siemes C., Visser L. E., Coebergh J.-W. W., et al. C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study. of Clinical Oncology. 2006;24(33):5216–5222. doi: 10.1200/jco.2006.07.1381.

Kiyohara C, Horiuchi T, Takayama K and Nakanishi Y. Genetic polymorphisms involved in the inflammatory response and lung cancer risk: a case-control study in Japan. Cytokine 2014; 65: 88-94.

Pankow JS, Folsom AR, Cushman M, Borecki IB, Hopkins PN, Eckfeldt JH, Tracy RP: Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study. Atherosclerosis 2001;154:681-9.

Sambrook J, Fritsch EF, Maniatis T (1989). Molecular Cloning: A

laboratory Manual (2nd Edition). Cold Spring Harbor Laboratory, New York.

Slattery ML, Curtin K, Poole EM, Duggan DJ, Samowitz WS, Peters U, Caan J, Potter JD, Ulrich CM : Genetic variation in C-reactive protein (CRP) in relation to colon and rectal cancer risk and survival. Int J Cancer2011; 128: 2726-2733,.

Lanwei Guo, Shuzheng Liu, Shaokai Zhang, Qiong Chen, Meng Zhang, Peiliang Quan, Jianbang Lu & Xibin SunC-reactive protein and risk of breast cancer: A systematic review and meta-analysis. Scientific Reports,2015; 5, 10508

Lee CC, You NC, Song Y, Hsu YH, Manson J, Nathan L, Tinker L, Liu S.: Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort. Clin Chem2009;

: 351-360,

.




DOI: http://dx.doi.org/10.52155/ijpsat.v6.1.177

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 Zafir Hassan Ghali

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.