Epidemiological and Cytological Profile of Pancytopenia in Hematology Laboratory of JRA University Hospital Antananarivo

Zolalaina Huberthine RAKOTOARIVELO, Marie Osé Michael HARIOLY NIRINA, Malalanandrianina Arinomenjanahary RAKOTOARISOA, Alain NTOE ZARA, Aimée Olivat RAKOTO ALSON, Andry RASAMINDRAKOTROKA

Abstract


Introduction: Pancytopenia is defined as simultaneous decrease of three myeloid lineages below normal values for age and sex. In Madagascar, few studies have analyzed profiles of patients with pancytopenia. Ours aims were to determine epidemiological, clinical, cytological and etiological profile of pancytopenia.

Methods: We collected all data from patients with pancytopenia over a period of 12 months (March 2013-March 2014) at hematology laboratory of CHU-JRA Antananarivo.

Results: 11843 hemograms were performed, pancytopenia accounted for 0.91% (108/11843). Eighty-three patients met the inclusion criteria of our study. The average age was 29.48 years old with extremes of 29 days and 83 years. There was a male predominance with a ratio of 1.18. Anemic syndrome is the most common clinical sign (Table 1). Hemogram study showed anemia to varying degrees. Twenty-six patients (31.32%) had a platelet count below 20G /L. Blood smear study revealed presence of blasts in 19.27% (16/83). Conclusion: Pancytopenia is fairly common circumstance in practice. Abnormalities in hemogram must involve further investigations.

Keywords


Pancytopenia; anemia, leukopenia, thrombopenia, hemogram, myelogram

Full Text:

PDF

References


H. Nafil, I. Tazi, M. Sifsalam, M. Bouchtia and L. Mahmal. Etiological profile of pancytopenia in adults in Marrakech (Morocco). EMHJ. 2012.18 No. 5 • 532-536

. Gupta V, Tripathi S, Tilak V, Bhatia BD. A study of clinico-haematological profiles of pancytopenia in children. Trop Doct. 2008 Oct;38(4):241-3.

Mobina Ahsan Dodhy, Nusrat Bokhari, Abbas Hayat. Aetiology of Pancytopenia, A five-year experience. Ann Pak Inst Med Sci Apr - Jun 2005;1(2):92-5.

Jha A, Sayami G, Adhikari RC, Panta AD, Jha R.Bone marrow examination in cases of pancytopenia.JNMA J Nepal Med Assoc. 2008 Jan-Mar; 47(169):12-7.

Gayathri BN, Rao KS. Pancytopenia: a clinico hematological study. J Lab Physicians. 2011 Jan; 3(1):15-20.

Shano Naseem1, Neelam Varma2, Reena Das2, Jasmina Ahluwalia2, Man Updesh Singh Sachdeva2, Ram Kumar Marwaha . Pediatric patients with bicytopenia/pancytopenia: Review of etiologies and clinico-hematological profile at a tertiary center. Indian journal of pathology and microbiology ; 2011: 54 (1): 75-80

Savage DG1, Allen RH, Gangaidzo IT, Levy LM, Gwanzura C, Moyo A, Mudenge B, Kiire C, Mukiibi J, Stabler SP, Lindenbaum J. Pancytopenia in Zimbabwe. Am J Med Sci. 1999 Jan;317(1):22-32.




DOI: http://dx.doi.org/10.52155/ijpsat.v17.1.1380

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 Zolalaina Huberthine RAKOTOARIVELO, Marie Osé Michael HARIOLY NIRINA, Malalanandrianina Arinomenjanahary RAKOTOARISOA, Alain NTOE ZARA, Aimée Olivat RAKOTO ALSON, Andry RASAMINDRAKOTROKA

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.